Novum telum in tuberculosis diagnosis et medicamento resistentia deprehendatur: nova generatio targeted sequencing (TNG) compositae cum apparatus cognita in tuberculosis hypersensitivity diagnosi
Literature Report: CCA: A Diagnostic Model fundatur in TNG et apparatus doctrina, quae est idoneam ad populum cum minus bacterial tuberculosis et tuberculoi Meningitis.
Thesis title: Tuberculous, targeted deinde-generationem sequencet et apparatus doctrina: an ultra-sensitivo diagnostic belli de paucifica pulmonalis tubulars et tubulares meningitis.
Periodical "Clinica Acta"
Si: 6.5
Date of Publication: January MMXXIV
Combined cum University of Chinese Academy of Sciences et Beijing Pectore hospitalis de Capital Medical University, Macro & Micro-test constituitur a tuberculosis diagnosis exemplar fundatur in nova generatione targeted sequencing (tngs) technology et apparatus disciplina (tngs) technology et apparatus disciplina (TGS) Deprehensio sensibilitate tuberculosis cum paucis bacteria et tuberculous Meningitis, provisum novum hypersensitivity diagnosis modum ad orci diagnosis de duobus Genera tuberculosis et adiuvisti ad accurate diagnosis, medicamento resistentia deprehensio et curatio tuberculosis. In eodem tempore, quod est inventus est patientes estote in plasma CFDNA potest esse ut idoneam specimen type pro orci sampling in diagnosis de tbm.
In hoc studio, CCXXVII Plasma exempla et cerebrospinal fluidum exempla sunt usus ad statuam duas orci cohortes, in quibus Laboratory Diagnostic cohortis exempla sunt ad constituere apparatus discendi exemplaria exempla sunt solebat cognoscere et Columbis Cohort Samples sunt solebant ut cognoscere et in Coloni Cohort Samples sunt solebant ut cognoscere in Cohors Exempla et usus est ut cognoscere in Cohors Exempla et in Clinical Her Diagnostic exemplar. Omnes exemplaria sunt primi targeted per specialiter disposito targeted captis specillo piscinam pro Mycobacterium tuberculosis. Deinde fundatur TB-tngs sequencing notitia, in arbitrium arbore exemplar adhibetur ad praestare V-complicare crucem-validation in exercitatione et sanatio sets de Laboratory Diagnostic Queue et Diagnostic Plasma Pure. Et adeptus est limen intulit in duo test occidere de orci diagnosis queue pro deprehendatur et diagnostic perficientur de discipuli est aestimari a Roc curva. Denique, in diagnosis exemplar tuberculosis est adeptus.
Fig. I schematic diagram of Research Design
Results: Secundum ad specifica in limolds CSF DNA Sample (AUC = 0.974) et Plasma CFDNA Sample (AUC = 0.908) determinari in hac studiis, in CCXXVII%, in specifica est 95.65% et Et sensitivity et specifica plasma sample erant 82,61% et 86,36%. In analysis de XLIV paribus exempla de Plasma CFDNA et cerebrospinal fluidi DNA ex TBM aegris, diagnostic belli huius studium habet princeps constantia de 90,91% (45.45% in Plasma et C. 95,45% (42/44). In filios cum pulmonis tuberculosis, diagnostic belli huius studium est sensitiva ad plasma exempla quam Xpert deprehensio eventus CARDIACUS sucus exempla ex eodem aegris (28.57% nobis 15.38%).
P. II analysis perficientur de tuberculosis diagnosis exemplar ad population samples
Fig. III Diagnostic results of paribus exempla
Conclusio: Hypersensitive Diagnostic modum in tuberculosis in hoc studium, quod potest providere diagnostic tool cum summo deprehendendis sensibilitatem ad orci aegris cum oligobacry Tuberculosis (cultus). Deprehensio Hypersensitive Tuberculosis secundum Plasma CFDNA sit apta sample typus ad diagnosis activae tuberculosis et Tuberculous MENDITIS (PLASMA exempla sunt facilius ad colligunt quam cerebrospolis fluidum pro aegris suspectus est quam cerebrospulosis fluidum pro aegris suspectus est cereberculosis fluidum pro aegris suspectus est cereberculostoleis fluidum est aegris suspectus cerebrum tuberculosis fluidum est aegros suspectus est cereberculosis fluidum est aegris suspectus cerebrum tuberculolis).
Original link: https://www.sciencedirect.com/science/article/pii/s0009898123004990? Per% 3Dihub
Brevis Macro & Micro-test tuberculosis series deprehendatur products
In visum de complicated sample situ tuberculosis aegris et variis necessitatibus, Macro & micro-test providet completum paro of NGS solutions pro liquefactionibus extraction ex Sputum exemplaria, Qualcom Library constructione et sequencing, et notitia analysis. In products operimentum celeri diagnosis de Tuberculosis aegris, medicamento resistentia deprehensionem Tuberculosis, typing of Mycobacterium tuberculosis et ntm, hypersensitivity diagnosis de Bacteria, negative tuberculosis et tuberculous populum, etc.
Vide Deprehensio Kits ad Tuberculosis et Mycobacteria:
| Item non | Product Name | Product testis contentus | Sample Type | applicabiles exemplum |
| HWTS-MMMXII | Sample Release Agent | In liquefaction curatio de sputum exempla, quae adeptus est prima-genus record numerus, sutong machina apparatu 20230047. | sputum | |
| HWTS, NGS, P00021 | Qualcomm quantitas deprehendatur ornamentum pro hypersensitive tuberculosis (Probe captis modum) | Non-Psidium (liquor biopsy) hypersensitivity deprehendatur ad Bacteria, negative pulmonalis tuberculosis et cerebrum nodules; The samples of people suspected to be infected with tuberculosis or non-tuberculosis mycobacteria were analyzed by high-depth sequencing metagenomics, and the detection information of whether tuberculosis or non-tuberculosis mycobacteria were infected and the main first-line drug resistance information of mycobacterium tuberculosis sunt provisum. | Periphericis sanguis, Alveolaris Lavage Liquor, Hydrothothorax et Ascites, Focus Punctura Sample, cerebrospinal fluidum. | Generatio |
| HWTS, NGS, T001 | Mycobacterium typing et medicamento resistentia deprehensionem ornamentum (multiplex amplificatio sequencing modum) | Mycobacterium typing test, comprehendo Mtbc et CLXXXVII NTMANTOLIUM;Medicamento resistentia Deprehensio Mycobacterium tuberculosis Covers XIII medicinae et XVI core mutationem sites of medicamento resistentia genes. | Sputum, Alveolaris Lavage Liquor, hydrothorax et Ascites, focus punctura system, cerebrospinal liquor. | Secundi / tertia generation dual platform |
Quisque ornare ipsum: HWTs, NGS, T001 Mycobacterium typing et medicamento resistentia deprehensionem ornamentum (multiplex amplificatio modum)
Product Introduction
Quod productum fundatur super pelagus primi et secundi-line medicinae descripsit in qui TB curatio guidelines, Macrolides et aminoglycosides communiter in NTM curatio omnes unum coetus a medicamento resistentia, related sites omnes in Cui Mycobacterium tuberculosis universa mutationem Catalog, tum alia relata medicamento resistentia genes et mutationem sites secundum ad investigationem et mutant High-mollis tristique literis domi et foris.
Typing idem fundatur in NTM Strans tormendaed in NTM guidelines published by Chinese Journal of Tuberculosis et respiratoriorum morbo et consensu peritorum. In disposito typing primers potest ampliari, sequentia et annotate plus quam CXC NTM speciei.
Per targeted multiplex PCR est technology, genatyping genes et medicamento repugnant genes Mycobacterium amplificari per multiplex PCLEX, et amplon coniuncta target genes ut deprehendatur. In ampliari products potest constructa in secunda generatione et tertia-generation summus throughput sequencing libraries et secundo generatione et tertia generationem sequencing tabulatis potest subiecta summus profundum sequencing consequi ordine notitia target genes. Per comparet cum notum mutationes continebat in aedificata-in reference database (including qui Mycobacterium tuberculosis universa mutationem catalog et eius necessitudinem cum medicamento resistentia), in Medicamine resistentia aut suscipit anti-tuberculosis medicaments vel suscipit. Cuncta cum auto-aperuit sputum sample curatio solutio Macro & micro-test, quaestio de humilis nucleic acidum amplificationem efficientiam de orci sputum modi (decem temporibus altius quam quod de traditional modos) solvitur potest directe applicantur ad orci sputum exemplaria.
Product Deprehensio dolor
34Medicamento resistentia related genes18Anti-tuberculosis medicamina et6NTM medicamina deprehenduntur, coveringCCXCVIIMedicamento resistentia sites; Decem genera Mycobacterium tuberculosisCXCgenera NTM deprehendi.
Table I: Information of XVIII + VI pharmaca + CXC + NTM
Product commodum
Fortis orci adaptability: et sputum exempla potest directe deprehendi cum auto-liquefactionem agente sine cultura.
Quod experimentum operatio est simplex, in primo circum ampliorem operationem est simplex, et bibliotheca constructione perficitur in III horas, quod amplio opus efficientiam.
Comprehensive typing et medicamento resistentia: covering typing et medicamento resistentia sites of MTB et NTM, quae sunt clavem puncta orci spectat, accurate typing et medicamento resistentia, supporting iuris analysis software et generating analysis tradit in unum click.
Compatibility: Product Compatibility, accommodatam ad mainstream ILM et MGI / ONT Platforms.
Product specificationem
| Product Code | Product Name | Deprehensio Platform | cubits |
| HWTS, NGS, T001 | Mycobacterium tuberculosis et pharmacum resistentia deprehensionem ornamentum (multiplex amplificatio modum) | Ont, illumina, MGI, Salus Pro | XVI / 96rxn |
Post tempus: Jan-23-2024