Clostridium difficile glutamate dehydrogenase (GDH) et toxin a / b

Clostridium difficile (CD) est obligate anaerobic gram, positivum Bacillus, quae est normalis floram in humano corpore. Alia Flora erit inhibuit a multiplicatione ex antibiotics in magna doses, et CD reproduces in humana corpus in copiosa. CD dividitur in toxin-producendo et non-toxin-producens speciei. Omnes CD species producendum glutamate dehydrogenase (GDH) cum reproducat, et solum toxigenic stramenta sunt morbificae. Toxin-producendo stasins potest producendum duo toxins, et B. toxin est an enterotoxin, quod potest inflammatio intestinorum murum, cell infiltration, auctus permeability murum, sanguineum et nonis in intestinorum murum, anus, et nonosis intestinorum, anus. Toxin B est Cytotoxin, quod damna Cytoskeleton, causat cellula Pyknosis et necrosis et directe dampna intestinorum parietal cellulis, unde in fluxus et pseudomembranous Colitis.