Humanum BCR-ABL Fusion Gene Mutatio

Description:

Hoc ornamentum aptum est ad detectionem qualitativae p190, p210 et p230 isoformum generum fusionis BCR-ABL in exemplis medullarum ossis humanarum.


Product Detail

Product Tags

Product nomen

HWTS-GE010A-Human BCR-ABL Fusion Gene Mutatio Detection Kit (Fluorescens PCR)

Epidemiologia

Myelogenousleukemia chronica (CML) est malignus morbus clonalis cellae caulis hematopoieticae.Plus quam 95% of CML aegroti Philadelphiam chromosomatum (Ph) in suis cellulis sanguineis portant.Praedominantis pathogenesis CML haec est: Fusio gene BCR-ABL formatur per translocationem inter abl proto-oncogene (Abelson murinam leukemia viralem oncogene homologum 1) chromosomatis longi brachii 9 (9q34) et regionis botri rupturae ( BCR) gene chromosomatis brachii longi 22 (22q11);Fusio interdum ab hoc gena enodata tyrosinam kinasem (TK) activitatem habet, et amni ejus vias significativas (ut RAS, PI3K, JAK/STAT) promovet ad divisionem cellam promovendam et apoptosin cellam inhibet, cellulas faciens maligne proliferate ac per hoc causando Eventum CML.BCR-ABL unus ex indicibus diagnosticis magni momenti CML.In dynamica mutatione sui gradus transcripti certa indicator prognosticorum iudicium de leukemia et adhiberi potest ad recursum leukemia post curationem praedicere.

Channel

FAM BCR-ABL fusionem gene
VIC/HEX Internum Imperium

Technical Parameters

Repono Liquid: ≤-18℃ In tenebris
Fasciae vita Liquid: 9 months
Specimen Type Medulla ossis exempla
LoD 1000 Copies/mL

Specification

 

Nulla crux reactivitas cum aliis generum fusione TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, PML-RARa
Applicabilis Instrumenta Acta Biosystems (VII)D Real-time PCR Systems

Acta Biosystems (VII)D Fast Verus-Tempus PCR Systems

QuantStudio® 5 Real-Time PCR Systems

SLAN-96P Real-time PCR Systems

LightCycler®480 Real-time PCR systema

LineGene 9600 Plus Real-time PCR Detection System

MA-6000 Real-time Quantitatis Thermal Cycler

BioRad CFX96 Real-time PCR System

BioRad CFX Opus 96 Real-time PCR System


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