Human CYP2C9 et VKORC1 Gene Polymorphismus

Description:

Hoc ornamentum in vitro qualitativo deprehensio polymorphismi CYP2C9*3 (rs1057910, 1075A>C) et VKORC1 (rs9923231, -1639G>A) in DNA genomica generis humani sanguinis exempla.


Product Detail

Product Tags

Product nomen

HWTS-GE014A-HUMAN CYP2C9 et VKORC1 Gene Polymorphismus Detection Kit (Fluorescens PCR)

Testimonium

CE/TFDA

Epidemiologia

Warfarin est oralis anticoagulans vulgo in praxi clinica praesenti adhibita, quae maxime destinatur ad impeditionem et curationem morborum thromboembolicorum.Sed warfarin fenestram contractam habet et multum variat inter gentes et personas.Statistici docuerunt differentiam dosis stabilis in diversis hominibus plusquam XX temporibus esse posse.Reactio adversa cruentis accidit in 15.2% aegrorum bellicosorum quolibet anno capientium, quorum 3.5% sanguinem funestum explicant.Studia pharmacogenomica demonstraverunt polymorphismum geneticum scopum enzyme VKORC1 et metabolicae enzyme CYP2C9 bellicae momenti esse momentum quod differentiam in dose bellica.Warfarin inhibitor specificus est Vitaminum K epoxide reductase (VKORC1), et sic concretionem factoris vetat synthesin vitaminum K involventem et anticoagulationem praebet.Plurimi studiorum significaverunt polymorphismum gene VKORC1 promotorem esse praecipuum factorem afficientium genus et differentias singularum in dose bellicae inquisitae.Warfarin metabolized a CYP2C9, et mutantes metabolismi bellicosi valde tardiores.Individua warfarin utentes periculo altiore (bis ad ter altiorem) sanguinis in usu praematuro habent.

Channel

FAM VKORC1 (-1639G>A)
CY5 CYP2C9*3
VIC/HEX IC

Technical Parameters

Repono Liquid: ≤-18℃
Fasciae vita XII mensibus
Specimen Type Nova EDTA anticoagulata sanguine
CV ≤5.0%
LoD 1.0ng/μL
Specification Nulla crux-reactividad cum aliis maximis consistentibus genomarum humanarum seriei (CYP2C19 generis humani, gene RPN2 humanus);mutatio CYP2C9*13 et VKORC1 (3730G>A) extra detectionem range huius ornamenti
Applicabilis Instrumenta Acta Biosystems (VII)D Real-time PCR Systems

Acta Biosystems (VII)D Fast Verus-Tempus PCR Systems

QuantStudio®5 Real-Time PCR Systems

SLAN-96P Real-time PCR Systems

LightCycler®480 Real-time PCR systema

LineGene 9600 Plus Real-time PCR Detection System

MA-6000 Real-time Quantitatis Thermal Cycler

BioRad CFX96 Real-time PCR System

BioRad CFX Opus 96 Real-time PCR System

Opus O

Commendatur extraction reagens: Macro & Micro-test Viralis DNA/RNA Kit (HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) et Macro & Micro-test Automatic Extractor Nucleici Acidi (HWTS- 3006).


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