Humanum Ros1 Fusion Gene Mutationem
Product Name
HWTS-TM009-Humanum Ros1 Fusion Gene Mutationem Deprehensio Kit (Fluorescence PCR)
Certificatorium
CE
Epidemiology
Ros1 est transmembrane Tyrosine Kinase de insulin receptor familia. Ros1 Fusion Gene est confirmatus ut alius momenti non-parva cellula pulmone cancer coegi gene. Sicut repraesentativum novi unique mocecular subype, in incidentiae Ros1 fusion gene in Nsclc de I% ad II% ROS1 maxime subeundes gene reaining in eius exons XXXII, XXXIV, XXXV et XXXVI, post id quod genes CD74 EZR, SLC34A2 et SDC4, quod mos permanere movere Ros1 Tyrosine Kinase regionem. Enormis activated Ros1 Kinase potest strenuus downstream signalling meatus ut ras / mapk / erk, Pi3k / akt / aktastasis, et jak3 / stat3, ita participating in proliferation, differentiaque et metastasis ex Tumore cellulis, et causing et metastasis ex Tumore cellulis et causing et metastasis ex Tumore cellulis, et causing et metastasis ex Tumore cellulis, et cancer. Inter Ros1 Fusion Mutationes, CD74 Ros1 Rationes circiter XLII%, EZR Rationes circiter XV%, SLC34A2 Rationes circiter XII%, et SDC4 Rationes circiter VII%. Studiis ostensum est quod atp-binding site de catalytic domain Ros1 Kinase et ATP-binding site alk kinase habere homology usque ad LXXVII%, ita alk tyrosine kinase parva Molecule inhibitor CRIZotinib et in manifesta In curatio NSCLC cum Fusion Mutationem Ros1. Ideo deprehendatur Ros1 fusione mutationes est praemissa et basis pro guiding usum CRIZotinib medicinae.
Channel
| Fam | Reactionem quiddam I, II, III et IV |
| Vic (Hex) | IV reactionem buffer |
Technical parametri
| Repono | ≤, XVIII ℃ |
| PLUTEUM-vitae | IX menses |
| Specimen Type | Paraffin-embedded pathologicum TEXTUS vel divisa samples |
| CV | <5.0% |
| Ct | ≤38 |
| LOD | Hoc ornamentum potest deprehendere fusionem mutationes ut low ut XX copies. |
| Applicabiles instrumenta: | Applicari Biosystems (VII) D Real-vicis PCR SystemsApplicari Biosystems (VII) D ieiunium realis-vicis PCR systems Slan ®-96p Real-vicis PCR systems QuantStudio ™ V Real-vicis PCR Systems LightcyCler®®®® Real-vicis PCR ratio Linenene (IX) DC plus realis-vicis PCR deprehensio ratio MA-(VI) Real-vicis quantitatis scelerisque cycler BIOD CFX96 Real-vicis PCR ratio BIOD CFX Opus XCVI Real-vicis PCR ratio |
ADMODO
Commendatur extraction Reagent: RNEAY FFPE Kit ((LXXIII) DIV) ex Qiagen, paraffin embedded TEXTUS SECTIO Total RNA extraction Kit (DP439) Ex Tiangen Biotech (Beijing) Co., Ltd.
