Human CYP2C9 et VKORC1 Gene Polymorphismus
Product nomen
HWTS-GE014A-HUMAN CYP2C9 et VKORC1 Gene Polymorphismus Detection Kit (Fluorescens PCR)
Testimonium
CE/TFDA
Epidemiologia
Warfarin est oralis anticoagulans vulgo in praxi clinica praesenti adhibita, quae maxime destinatur ad impeditionem et curationem morborum thromboembolicorum.Sed warfarin fenestram contractam habet et multum variat inter gentes et personas.Statistici docuerunt differentiam dosis stabilis in diversis hominibus plusquam XX temporibus esse posse.Reactio adversa cruentis accidit in 15.2% aegrorum bellicosorum quolibet anno capientium, quorum 3.5% sanguinem funestum explicant.Studia pharmacogenomica demonstraverunt polymorphismum geneticum scopum enzyme VKORC1 et metabolicae enzyme CYP2C9 bellicae momenti esse momentum quod differentiam in dose bellica.Warfarin inhibitor specificus est Vitaminum K epoxide reductase (VKORC1), et sic concretionem factoris vetat synthesin vitaminum K involventem et anticoagulationem praebet.Plurimi studiorum significaverunt polymorphismum gene VKORC1 promotorem esse praecipuum factorem afficientium genus et differentias singularum in dose bellicae inquisitae.Warfarin metabolized a CYP2C9, et mutantes metabolismi bellicosi valde tardiores.Individua warfarin utentes periculo altiore (bis ad ter altiorem) sanguinis in usu praematuro habent.
Channel
| FAM | VKORC1 (-1639G>A) |
| CY5 | CYP2C9*3 |
| VIC/HEX | IC |
Technical Parameters
| Repono | Liquid: ≤-18℃ |
| Fasciae vita | XII mensibus |
| Specimen Type | Nova EDTA anticoagulata sanguine |
| CV | ≤5.0% |
| LoD | 1.0ng/μL |
| Specification | Nulla crux-reactividad cum aliis maximis consistentibus genomarum humanarum seriei (CYP2C19 generis humani, gene RPN2 humanus);mutatio CYP2C9*13 et VKORC1 (3730G>A) extra detectionem range huius ornamenti |
| Applicabilis Instrumenta | Acta Biosystems (VII)D Real-time PCR Systems Acta Biosystems (VII)D Fast Verus-Tempus PCR Systems QuantStudio®5 Real-Time PCR Systems SLAN-96P Real-time PCR Systems LightCycler®480 Real-time PCR systema LineGene 9600 Plus Real-time PCR Detection System MA-6000 Real-time Quantitatis Thermal Cycler BioRad CFX96 Real-time PCR System BioRad CFX Opus 96 Real-time PCR System |
Opus O
Commendatur extraction reagens: Macro & Micro-test Viralis DNA/RNA Kit (HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) et Macro & Micro-test Automatic Extractor Nucleici Acidi (HWTS- 3006).
