Humanum Cyp2c9 et Vkornc1 Gene Polymorphism
Product Name
HWTS, GE014A-Humanum CYP2C9 et Vkorc1 Gene Polymorphism Deprehensio Kit (Fluorescence PCR)
Certificatorium
Ce / tfda
Epidemiology
Warfarin est oris anticoagulant communiter in orci usu currently, quod est maxime in animo ad praeventionis et curatio of thromboembolic morbis. Tamen, Warfarin habet limitata curatio fenestra et variatur valde in diversis gentibus et hominum. Statistics indicavit quod differentia stabilis dose in diversis hominum potest esse plus XX temporibus. Et adversa reactionem sanguinem occurs in 15,2% de aegris taking warfarin per annum, cuius 3.5% develop exitiale sanguinem. Pharmacogenomic studiis ostensum est quod geneticae polymorphism de scopum enzyme Vkornc1 et metabolicae enzyme CYP2C9 de Warfarin est momenti factor afficiens differentia in dose of Warfarin. Warfarin est specifica inhibitor de Vitamin K epoxide reductase (Vkornc1), et sic inhibits vester factor synthesis involving Vitaminum K et providet Anticoagulation. A numerus of studiis indicavit quod gene polymorphism de Vkornc1 promotor est maxime momenti factor afficiens genus et singula differentias in requiratur dose of Warfarin. Warfarin est metabolized per CYP2C9 et mutants valde tardius metabolism beller. Individua per Warfarin habere altiorem periculo (bis in ter superior) de sanguinem in mane scaena usum.
Channel
| Fam | Vkornc1 (-1639G> A) |
| CYV | CYP2C9 * III |
| Vic / Hex | IC |
Technical parametri
| Repono | Liquid: ≤, XVIII ℃ |
| PLUTEUM-vitae | XII mensibus |
| Specimen Type | Nova EDTA Anticoagulated sanguis |
| CV | ≤5.0% |
| LOD | 1.0ng / μl |
| Specifica | Non est crucem-reactivity cum alii altus consistent sequentia de humano genome (Humanum CYP2C19 gene, humana rpn2 gene); Cyp2c9 * XIII et Vkornc1 mutationem (3730g> a) extra Deprehensio range huius ornamentum |
| COMPRESSUS | Applicari Biosystems (VII) D Real-vicis PCR Systems Applicari Biosystems (VII) D ieiunium realis-vicis PCR systems QuantStudio®5 Real-vicis PCR Systems Slan-96P realis-vicis PCR systems LightcyCler®®®® Real-vicis PCR ratio Linenene (IX) DC plus realis-vicis PCR deprehensio ratio MA-(VI) Real-vicis quantitatis scelerisque cycler BIOD CFX96 Real-vicis PCR ratio BIOD CFX Opus XCVI Real-vicis PCR ratio |
ADMODO
Commendatur extraction Reagent: Macro & Micro-test viral DNA / RNA Kit (HWTS-MMMI, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) et Macro & Micro-Test Automatic Nucleiic Acidum extractor (HWTS- MMMVI).
